Melanocytic nevus histopathology pdf

Pathology of melanocytic nevi and malignant melanoma. Sun exposure is a causative factor, particularly in childhood. Genital pigmented lesions include lentiginosis, blue nevus, common melanocytic nevus, spitz nevus, dysplastic melanocytic nevus. Acquired melanoyctic naevus or mole is a common benign tumour, usually appearing during childhood and adolescence. Pathology of melanocytic nevi and malignant melanoma request. Distinguishing between benign and malignant melanocytic nevi by. Melanocytic proliferations are composed of one or more of three related types of cells. Congenital melanocytic nevus cmn is defined as a benign proliferative skin disease in the epidermis and dermis. Both lesions have about 30 cases each reported in english literature. Spontaneous regression of a congenital melanocytic nevus article pdf available in indian journal of dermatology, venereology and leprology 774. Clinical and histopathological characteristics of genital melanocytic.

It is usually apparent at birth and progressively grows with individuals, with an incidence rate in newborns of approximately 12% and no sexual bias 1, 2. Compound melanocytic nevus histopathology filip sokol. Pathology study group devoted to the histology of benign melanocytic nevi table 1 was convened on march. Although the majority of these lesions can be confidently diagnosed using wellestablished morphologic criteria, there is a significant subset of lesions. Melanocytic lesions are common in routine surgical pathology. Immunohistochemical expression of p16 in melanocytic lesions. These naevi have been termed naevi of special sites or naevi with siterelated atypia as distinctive features have been correlated with specific anatomic sites. Often clusters of chronic inflammatory cells at base of nevus. A point mutation in the braf gene most often v600e is usually the initiating genetic mutation.

It was first described in 1948 but great controversy still remains today. Melanocytic lesions of the prostate maria estela pompeu do amaral1 and daniel abensur athanazio1,2 abstract background. Dermal melanocytes or nests are separated by collagenous stroma. Benign melanocytic lesions of the prostate are rare and classified as blue nevus or melanosis. The spitz nevus is a benign melanocytic lesion with clinical and histopathological features similar to those of melanoma. A practical approach to the diagnosis of melanocytic lesions nathan t. Melanocytes, nevus cells or melanoma cells, each of. Melanocytic lesions are common and include both benign and malignant conditions. Histopathological characteristics of small diameter melanocytic naevi. Melanocytic naevi of special sites diagnostic histopathology. Part 1 of my in progress video series about the pathology of melanocytic skin lesions. Dermal component consists of nests may be very large or linear pattern of melanocytes, cells are small with scant cytoplasm and regular nuclei and mature with depth by becoming more slender spindled with less pigment. A practical approach to the diagnosis of melanocytic lesions. Giant congenital melanocytic nevi are most simply defined as melanocytic nevi that are greater than 20 cm in largest dimension.

Pdf spontaneous regression of a congenital melanocytic nevus. An exclusive epithelioid morphology was observed in atypical compound nevi 41. Request pdf pathology of melanocytic nevi and malignant melanoma highly acclaimed and considered the leading reference in the field, pathology of. Representative mpm images of a dysplastic nevus along with corresponding histology are shown in figure 3. Histopathological spectrum of benign melanocytic nevi our. Histopathological diagnosis of small melanocytic lesions suspicious.

There is a recently recognized and relatively common group of melanocytic naevi that share histopathologic features in common with dysplastic naevi and malignant melanoma. Diagnosis of malignant melanoma is currently a 2tiered process beginning. Lesions evolve with age, the initial lesion being macular with nests of proliferating. Cmns can be characterized as a papular, rugose, pebbly.